Antinociceptive and anti-inflammatory effects of Tanacetum parthenium L. extract in mice and rats.
نویسندگان
چکیده
Oral administration of the feverfew (Tanacetum parthenium) extract led to significant antinociceptive and anti-inflammatory effects against acetic acid-induced writhing in mice and carrageenan-induced paw edema in rats, respectively. These responses were dose-dependent (10, 20, 40 mg/kg, p.o.). Parthenolide (1, 2 mg/kg i.p.), the active constituent of the extract also produced antinociceptive and anti-inflammatory effects. Naloxone (1 mg/kg i.p.), an opiate antagonist, failed to reverse feverfew extract and parthenolide-induced antinociception. Feverfew extract in higher doses (40, 60 mg/kg p.o.) neither altered the locomotor activity nor potentiated the pentobarbitone-induced sleep time in mice. It also did not change the rectal temperature in rats. Feverfew extract exerted antinociceptive and anti-inflammatory effects without altering the normal behaviour of the animals.
منابع مشابه
Radioprotective and antioxidant potential of Tanacetum parthenium extract and synthetic parthenolide in Swiss albino mice exposed to electron beam irradiation
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ورودعنوان ژورنال:
- Journal of ethnopharmacology
دوره 68 1-3 شماره
صفحات -
تاریخ انتشار 1999